Cardiovascular Toxicity of Local Anesthetics
نویسندگان
چکیده
In general, much greater doses of local anesthetics are required to produce cardiovascular (CV) toxicity than CNS toxicity. Similar to CNS toxicity, potency for CV toxicity reflects the anesthetic potency of the agent. Recent attention has focused on the apparently exceptional cardiotoxicity of the more potent, more lipid-soluble agents (bupivacaine, levo-bupivacaine, etidocaine, ropivacaine). These agents appear to have a different sequence of CV toxicity than less potent agents. For example, increasing doses of lidocaine leads to hypotension, bradycardia, and hypoxia, whereas bupivacaine often results in sudden cardiovascular collapse due to ventricular dysrhythmias that are resistant to resuscitation. Subsequent studies have identified multiple mechanisms in the CNS and CV system for increased cardiotoxicity from potent local anesthetics.
منابع مشابه
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